Which drug is associated with hypotension during rapid infusion?

Etoposide is associated with hypotension when infused rapidly due to its pharmacological effects and the way it interacts with the cardiovascular system. During rapid infusion, the drug can cause vasodilation and affect the body's ability to maintain normal blood pressure. This reaction can occur as a direct result of the drug's action, which includes inhibition of topoisomerase II, leading to rapid cell death and release of inflammatory mediators that may further contribute to vascular changes.

It is important to consider that other agents may have their own infusion-related side effects, but etoposide's specific risk for hypotension during rapid administration is well-documented. The clinical practice surrounding the administration of etoposide includes recommendations to infuse it slowly to minimize this potential adverse effect and to monitor the patient's blood pressure closely during the infusion. This knowledge is crucial for nurses and healthcare providers in order to ensure patient safety and effective management during chemotherapy treatments.