Which chemotherapy drug has side effects including mucositis and seizures?

Busulfan is an alkylating agent that is primarily used in the treatment of certain leukemias and to prepare patients for bone marrow transplantation. One of the notable side effects associated with busulfan is mucositis, which is inflammation and ulceration of the mucous membranes in the mouth and gastrointestinal tract. This can lead to significant discomfort and difficulty in eating and swallowing.

In addition to mucositis, busulfan can also cause neurological side effects, including seizures. These seizures are particularly concerning and have been documented in patients receiving high doses or those who have underlying risk factors that may predispose them to seizures. This specific side effect profile highlights the need for careful monitoring and potential seizure prophylaxis in patients undergoing treatment with busulfan.

While other chemotherapy agents, such as cisplatin and carboplatin, come with their own distinct side effects, they do not typically include seizures as a notable complication. Carmustine, while also having its own side effects, is not primarily linked with seizures in the way that busulfan is. Understanding the specific side effect profiles of chemotherapy drugs is critical for management and supportive care in oncology practice.