What symptom does cytarabine potentially cause at higher doses?

Cytarabine, particularly at higher doses, is known to potentially cause conjunctivitis. This is an inflammation of the conjunctiva, which can manifest as redness, irritation, and discomfort in the eyes. The mechanism behind this side effect is thought to involve the drug's impact on rapidly proliferating cells, which includes those in the conjunctival tissue.

Understanding this side effect is important in the clinical management of patients receiving high doses of cytarabine, as timely recognition and intervention (such as the use of corticosteroids or artificial tears) can help alleviate discomfort and maintain quality of life during treatment.

Although nausea, edema, and dermatitis can occur with various chemotherapeutic agents, they are not specifically prominent side effects associated with higher doses of cytarabine. Thus, recognizing conjunctivitis as a notable side effect is crucial for healthcare providers managing patients on this medication.