What significant potential side effect should be monitored closely in patients receiving cisplatin?

Cisplatin is a platinum-based chemotherapeutic agent that is commonly used to treat various types of cancer. One of its significant potential side effects is nephrotoxicity, which refers to damage to the kidneys. This adverse effect is particularly concerning because the kidneys play a crucial role in filtering and excreting drugs and their metabolites from the body.

Patients receiving cisplatin may experience renal impairment, which can manifest as elevated serum creatinine levels, decreased urine output, and electrolyte imbalances. The risk of nephrotoxicity can be exacerbated by factors such as high doses of cisplatin, pre-existing kidney conditions, dehydration, and concurrent use of other nephrotoxic medications. Therefore, it is essential for healthcare providers to closely monitor renal function through regular blood tests, hydration protocols, and adjusting doses as necessary to mitigate the risk of kidney damage.

Other side effects associated with cisplatin can occur, but nephrotoxicity remains one of the most critical and common complications that require vigilant monitoring and management in clinical practice. By identifying nephrotoxicity early, healthcare professionals can take appropriate steps to protect the patient's kidney function during treatment with cisplatin.