What percentage of a humanized monoclonal antibody is derived from human sources?

The correct answer indicates that 90% of a humanized monoclonal antibody is derived from human sources. Humanized monoclonal antibodies are designed to be more effective and less immunogenic compared to fully murine (mouse-derived) antibodies.

In the process of humanization, a considerable portion of the antibody’s structure (specifically the framework regions) is replaced with human immunoglobulin sequences while maintaining the antigen-binding sites from the original murine antibody. This design allows the antibody to be recognized by the human immune system more easily and minimizes the chances of an immune response against the therapeutic product.

Humanized antibodies retain the effectiveness of the original murine antibodies while enhancing safety and tolerability for patients. This blend of human and murine components results in the figure of approximately 90%, which reflects a high degree of human origin while still leveraging the unique binding capabilities of the murine antibody's specific variable regions.