What is a major side effect of paclitaxel?

The major side effect of paclitaxel, particularly in the context of chemotherapy, is known to be chills. This reaction can occur as a result of histamine release during the infusion process of the medication. Paclitaxel is a taxane drug that is commonly used in the treatment of various cancers, including breast, ovarian, and lung cancer. Chills may accompany other infusion-related reactions, including fever and hypotension, due to the body's response to the drug's introduction into the bloodstream.

The mechanism behind this side effect is not completely understood but is linked to the way certain chemotherapeutic agents, like paclitaxel, interact with the immune system and the body’s response to foreign substances. This is particularly relevant when considering the required premedication often employed with paclitaxel administration to mitigate such infusion reactions. Understanding the occurrence of chills as a primary side effect is critical for patient education and preparation, ensuring that individuals receiving paclitaxel are aware of possible reactions and can be monitored effectively during treatment.