Nelarabine is particularly known for which serious side effect?

Nelarabine is particularly associated with neurotoxicity, making it an important consideration in clinical practice. Neurotoxicity may manifest as symptoms such as confusion, seizures, or various neurologic deficits. This side effect arises because nelarabine, a nucleoside analog of guanosine, is primarily used in the treatment of certain leukemias, which can influence the central nervous system.

Monitoring for signs of neurotoxicity is critical, especially since it can significantly impact a patient's quality of life, treatment adherence, and overall treatment outcome. Awareness of this potential side effect can help healthcare providers implement early interventions if neurological symptoms arise, thus improving patient safety and care management.