Ifosfamide requires which of the following to minimize side effects?

Ifosfamide is known to have certain side effects, particularly related to the urinary system and renal function. Prehydration is critical when using ifosfamide because it helps to prevent the formation of urotoxic metabolites, specifically acrolein, which can lead to hemorrhagic cystitis. By ensuring that the patient is well-hydrated, the urine output is increased, which dilutes these toxic metabolites and flushes them out of the bladder more efficiently. This hydration strategy is important both before and after administering ifosfamide to support kidney function and reduce the risk of urinary tract complications.

Other strategies like stimulating appetite, using cryotherapy, or administering with anisette do not directly address the specific side effects associated with ifosfamide and are not standard practices for mitigating its toxicity. Thus, prehydration stands out as the appropriate and effective measure to minimize the adverse effects of ifosfamide treatment.