How should the IV line be managed around the administration of oxaliplatin?

Flushing the IV line with D5W (5% dextrose in water) around the administration of oxaliplatin is correct because oxaliplatin is known for its compatibility with dextrose solutions. This practice helps in ensuring that the drug is fully delivered and prevents any potential irritation or complications that might arise from using saline in this specific context. D5W helps maintain the osmolarity of the infusion, which is beneficial for the stability of the drug.

Saline flushing is generally acceptable for many medications; however, oxaliplatin can sometimes precipitate when mixed with saline or flushed with saline, which could potentially lead to complications or reduced efficacy. Therefore, using D5W is recommended to avoid such issues. Moreover, flushing immediately with D5W after oxaliplatin administration helps to clear the line effectively, ensuring that the patient receives the full intended dose and minimizes the risk of any drug interaction that may arise from incompatible solutions.